Description

Tirz Vial — Dual GIP/GLP-1 Receptor Agonist for Incretin Research (30mg)

What is Tirz?

Tirz is a synthetic 39-amino acid peptide that functions as a dual agonist of the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. It is a linear synthetic polypeptide with a molecular weight of approximately 4813 Da. The peptide is engineered by incorporating a C20 fatty diacid moiety that enables albumin binding, which contributes to its extended pharmacokinetic profile in research models.

What makes Tirz particularly interesting in metabolic research is that it is the first dual incretin receptor agonist to reach widespread research adoption. Unlike earlier single-pathway approaches, the dual mechanism simultaneously targets both major incretin receptor systems — GIP and GLP-1 — which are expressed across multiple tissues including pancreatic beta cells, the central nervous system, and adipose tissue.

Mechanism of Research Interest

Tirz functions by binding to and activating two distinct receptor types:

• GIP Receptor (GIPR): A class B G-protein-coupled receptor predominantly expressed on pancreatic beta cells, adipocytes, and in the central nervous system. Activation of GIPR triggers downstream signalling through adenylyl cyclase and cyclic AMP (cAMP) pathways. GIP receptor activity is associated with nutrient-dependent hormone secretion and lipid metabolism signalling.
• GLP-1 Receptor (GLP-1R): A class B GPCR expressed on pancreatic beta cells, neurons, and gastrointestinal tissue. GLP-1R activation similarly uses cAMP-dependent pathways and is associated with signalling pathways involved in appetite regulation, gastric motility, and glucose-dependent hormone secretion.

The dual-receptor approach of Tirz enables researchers to investigate how simultaneous activation of these two complementary incretin pathways influences systemic metabolic signalling, potentially revealing synergistic or additive effects that cannot be observed with single-receptor agonists alone.

Product Description

This product is a lyophilised (freeze-dried) sterile powder containing 30mg of Tirz peptide per vial. The lyophilised format provides excellent long-term stability when stored correctly, as the removal of water prevents hydrolysis and microbial growth during storage. The powder is designed to be reconstituted with bacteriostatic water or sterile saline solution prior to laboratory use.

Each vial is manufactured under controlled laboratory conditions and sealed under sterile vacuum to maintain peptide integrity. The white lyophilised cake or powder should appear as a uniform, free-flowing solid with no discolouration.

Research Applications

Tirz is of significant interest in the following research areas:

• Incretin Signalling Pathways: Investigating how GIP and GLP-1 receptor activation differentially regulate downstream signalling cascades.
• Dual-Receptor Pharmacology: Understanding the pharmacodynamic interaction between concurrent GIPR and GLP-1R activation.
• Metabolic Regulation Studies: Research into how dual incretin agonism affects energy balance, substrate metabolism, and nutrient partitioning.
• Comparative Receptor Studies: Comparing dual-receptor agonism against single-receptor approaches to identify pathway-specific vs. shared signalling outcomes.

Product Specifications

• Compound: Tirz (Dual GIP/GLP-1 Receptor Agonist)
• Molecular Weight: ~4,813 Da
• Sequence Length: 39 amino acids
• Quantity: 30mg per vial
• Purity: ≥98% (HPLC verified)
• Form: Lyophilised (freeze-dried) sterile powder
• Appearance: White to off-white lyophilised cake
• Packaging: Individually sealed sterile glass vial with rubber stopper and aluminium crimp seal
• Storage: Store at 2-8°C (refrigerated). Protect from light and moisture. Reconstituted solutions should be used promptly and stored at 2-8°C.
• Shelf Life: 24 months from date of manufacture (lyophilised)

Handling & Reconstitution Guidelines

For experienced laboratory personnel only. This product is a research-grade chemical and should be handled with appropriate personal protective equipment including gloves and eye protection. Reconstitute with bacteriostatic water for injection (BWFI) or sterile water for research use. Gently swirl — do not vigorously shake — to avoid denaturing the peptide structure. Visually inspect for particulate matter after reconstitution.

Quality & Sourcing

All Cronopharm peptides are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure peptide integrity throughout the supply chain.

What’s Included

Each order includes 1 × 3ml Bacteriostatic Water (BAC Water) for reconstituting the lyophilised powder. No additional reconstitution solution is required.

Key Research Benefits

• Dual Incretin Agonism: First-generation dual GIP/GLP-1 receptor agonist for incretin research.
• Albumin-Binding Design: C20 fatty diacid moiety supports extended pharmacokinetic studies.
• Multi-Tissue Expression: Beta cell, CNS and adipose GIPR/GLP-1R signalling research.
• Synergy Investigation: Studies additive effects of dual-receptor activation vs single agonists.

Important Notice

This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research peptides.