Description
KPV Vial — Anti-Inflammatory Tripeptide for Immune Research (10mg)
What is KPV?
KPV is a naturally occurring tripeptide composed of lysine, proline and valine (Lys-Pro-Val). It represents the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH), a melanocortin peptide with well-documented immunomodulatory properties.
Despite its minimal size, KPV retains significant biological activity and is studied as a standalone peptide for its anti-inflammatory and tissue-protective effects. It is investigated in models of intestinal inflammation, skin inflammation and immune cell signalling.
Mechanism of Research Interest
- Inflammatory Cytokine Modulation: Studied for effects on pro-inflammatory cytokine production in macrophage and epithelial cell models.
- Melanocortin Receptor Interaction: Investigated for partial agonism at melanocortin receptors expressed on immune cells.
- Epithelial Protection: Research examines protective effects on intestinal and dermal epithelial barriers under inflammatory challenge.
- NF-κB Pathway Research: Explored for modulation of NF-κB-dependent inflammatory gene expression.
Research Applications
- Inflammation signalling pathway research
- Intestinal and mucosal immunity studies
- Immune cell cytokine assays
- Anti-inflammatory peptide mechanism studies
Product Specifications
- Compound: KPV (Lys-Pro-Val tripeptide)
- Sequence Length: 3 amino acids
- Source: C-terminal fragment of α-MSH
- Quantity: 10mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilised (freeze-dried) sterile powder
- Appearance: White to off-white lyophilised cake
- Packaging: Individually sealed sterile glass vial
- Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.
What’s Included
Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.
Quality & Sourcing
All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.
Key Research Benefits
- Anti-Inflammatory Tripeptide: α-MSH C-terminal fragment studied for inflammatory cytokine modulation.
- Minimal Size, Defined Activity: 3-amino acid peptide ideal for structure-activity relationship studies.
- Mucosal Immunity Research: Investigated in intestinal and dermal epithelial inflammation models.
- NF-κB Pathway Studies: Explored for modulation of NF-κB-dependent inflammatory gene expression.
Reconstitution Guidelines
For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.
- Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
- Wipe the rubber stopper with an alcohol swab and allow it to dry.
- Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
- Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
- Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
- Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.
Important Notice
This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.
