Description

Semaglutide Pre-Filled Pen — GLP-1 Receptor Agonist Research Formulation

Formulation Overview

The Semaglutide Pre-Filled Pen provides a GLP-1 (glucagon-like peptide-1) receptor agonist in a sterile, ready-to-use format. Semaglutide is a 31-amino acid synthetic analogue of the human incretin hormone GLP-1, incorporating key modifications including a C18 fatty diacid side chain (for albumin binding and extended half-life) and an amino acid substitution that protects against DPP-4 enzyme degradation.

This pre-filled pen format offers the convenience of precise, pre-measured dosing without the need for reconstitution or vial handling — reducing protocol variables and simplifying administration in research settings.

GLP-1 Signalling Research

Semaglutide is one of the most extensively studied GLP-1 receptor agonists in the metabolic research literature. The GLP-1 receptor is a class B GPCR expressed across multiple tissue types including pancreatic islets, the central nervous system, gastrointestinal tract, heart, and kidney. GLP-1R activation triggers cAMP-dependent signalling cascades via Gs protein coupling, influencing diverse cellular processes depending on tissue context.

Research Applications

• Incretin Signalling: Investigating GLP-1 receptor-mediated signalling pathways including cAMP/PKA and EPAC activation in pancreatic, neural, and gastrointestinal tissues.
• Appetite Regulation Studies: Researching GLP-1R activation in hypothalamic and brainstem appetite centres.
• Gastric Function Studies: Examining the relationship between GLP-1 receptor activation and gastric emptying, gut motility, and gastrointestinal signalling.
• Glucose Metabolism Research: Exploring incretin effects on glucose-dependent hormone secretion and glucose homeostasis.
• Tissue-Specific Receptor Studies: Characterising GLP-1R expression and signalling across different tissue types.

Product Specifications

• Compound: Semaglutide (GLP-1 Receptor Agonist)
• Peptide Length: 31 amino acids
• Key Modification: C18 fatty diacid side chain + DPP-4 resistant substitution
• Format: Pre-filled, sterile, ready-to-use pen
• Presentation: Sterile solution
• Quality: Manufactured under controlled conditions with quality verification
• Storage: 2-8°C (refrigerated). Protect from light.

Key Research Benefits

• Potent GLP-1R Agonism: Highly potent GLP-1 receptor agonist with modifications (C18 fatty diacid, DPP-4 resistance) for extended-activity signalling research.
• Ready-to-Use Format: Sterile, pre-measured solution — no reconstitution required, simplifying research workflows.
• Broad Tissue Research: GLP-1R expressed in pancreatic, neural, GI, cardiac and adipose tissue — supports multi-tissue signalling studies.
• Precise Dosing: Pre-filled pen format provides accurate, reproducible doses for repeat-administration protocols.

How to Use (Research Application)

For experienced laboratory personnel only. This product is a sterile, ready-to-use pre-filled pen for research applications — no reconstitution required.

• Remove the pen from refrigeration and allow it to reach room temperature before use.
• Select the required dose on the pen dial as defined in your research protocol.
• Use sterile technique and attach a fresh needle for each administration.
• Rotate administration sites according to your research protocol.
• Store the pen at 2–8°C when not in use. Do not freeze. Dispose of used needles safely.

Important Notice

This product is for research and laboratory purposes only. Not for human or veterinary consumption. Not for medical use. Not evaluated by SAHPRA. For experienced researchers only. Information is for educational reference. Researchers must comply with all applicable regulations.