Description
GHK-Cu Vial — Copper Tripeptide for Tissue Remodelling Research (100mg)
What is GHK-Cu?
GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine and lysine (Gly-His-Lys). It was first isolated from human plasma and is found in tissues, saliva and urine. The peptide forms a stable complex with copper ions (Cu²⁺), and it is this complex that carries out its biological activities.
The GHK-Cu complex is studied extensively for its effects on collagen production, wound healing and tissue remodelling. As a copper chaperone, it delivers copper to enzymes that require the metal as a cofactor, including those involved in extracellular matrix synthesis and antioxidant defence.
Mechanism of Research Interest
- Collagen Synthesis: Stimulates the production of collagen and other extracellular matrix components in fibroblast cell models.
- Copper Delivery: Functions as a copper transport peptide, modulating the activity of copper-dependent enzymes such as superoxide dismutase and lysyl oxidase.
- Tissue Remodelling: Influences the balance of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), regulating matrix turnover.
- Antioxidant Signalling: Upregulates antioxidant gene expression, reducing oxidative stress markers in cell models.
Research Applications
- Collagen and extracellular matrix research
- Wound healing and tissue repair models
- Skin and dermal remodelling studies
- Copper metabolism and enzyme research
Product Specifications
- Compound: GHK-Cu (Gly-His-Lys copper tripeptide)
- Sequence Length: 3 amino acids
- Quantity: 100mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilised (freeze-dried) sterile powder
- Appearance: Light blue to off-white lyophilised cake
- Packaging: Individually sealed sterile glass vial
- Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.
What’s Included
Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.
Quality & Sourcing
All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.
Key Research Benefits
- Copper Delivery Peptide: Natural Gly-His-Lys tripeptide that chaperones copper to dependent enzymes.
- Collagen Research: Stimulates collagen and extracellular matrix synthesis in fibroblast models.
- Tissue Remodelling: Modulates MMP/TIMP balance for matrix turnover studies.
- Antioxidant Signalling: Upregulates antioxidant gene expression in cell models.
Reconstitution Guidelines
For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.
- Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
- Wipe the rubber stopper with an alcohol swab and allow it to dry.
- Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
- Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
- Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
- Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.
Important Notice
This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.
