Description

Tesamorelin Vial — GHRH Analogue for Endocrine Research (20mg)

What is Tesamorelin?

Tesamorelin is a synthetic 44-amino acid linear peptide that is structurally identical to the full-length sequence of human growth hormone-releasing hormone (GHRH 1-44). Unlike truncated GHRH analogues that contain only the bioactive N-terminal fragment, Tesamorelin includes the complete GHRH sequence, providing the full native peptide for endocrine research.

Growth hormone-releasing hormone (GHRH), also known as somatocrinin or growth hormone-releasing factor (GRF, GHRF), is produced by neurosecretory neurons in the arcuate nucleus of the hypothalamus. It is released into the hypothalamic-pituitary portal circulation and transported to the anterior pituitary, where it binds to GHRH receptors on somatotroph cells.

Mechanism of Action

Tesamorelin binds specifically to the GHRH receptor (GHRH-R), a class B G-protein-coupled receptor expressed on the surface of somatotroph cells in the anterior pituitary. Receptor binding activates the Gs alpha subunit, stimulating adenylyl cyclase and increasing intracellular cAMP. The resulting activation of protein kinase A (PKA) and downstream transcription factors (including CREB and Pit-1) promotes the synthesis and pulsatile secretion of growth hormone (GH).

The GH released from the pituitary then travels through the systemic circulation to stimulate hepatic production of insulin-like growth factor 1 (IGF-1), which mediates many of the peripheral effects of GH signalling. This GHRH-GH-IGF-1 axis is the central endocrine pathway regulating growth, metabolism, and body composition throughout life.

Research Applications

• Growth Hormone Axis Research: Investigating the GHRH-GH-IGF-1 signalling cascade from hypothalamic release through pituitary activation to peripheral mediator production.
• Pituitary Somatotroph Function: Studying somatotroph cell biology, GH secretory dynamics, and feedback regulation mechanisms.
• Endocrine Regulation: Exploring hypothalamic-pituitary feedback loops including somatostatin-mediated inhibition and GH/IGF-1 negative feedback.
• Metabolic Research: Investigating the relationship between GH axis signalling and metabolic processes including protein synthesis, lipid metabolism, and energy balance.
• Pulsatile Secretion Studies: Researching the mechanisms of pulsatile GH release and its physiological significance.

Product Description

Each vial contains 20mg of lyophilised Tesamorelin peptide as a sterile, freeze-dried preparation. The full-length 44-amino acid peptide is supplied as a white to off-white lyophilised powder in a sealed glass vial with rubber stopper and aluminium crimp seal.

Manufactured under controlled laboratory conditions with quality testing to verify peptide identity, purity, and content. The lyophilised format provides stability during transport and long-term refrigerated storage.

Product Specifications

• Compound: Tesamorelin (Full-Length GHRH 1-44 Analogue)
• Sequence: Identical to human GHRH 1-44
• Amino Acid Length: 44
• Hormone Class: Hypothalamic releasing hormone
• Receptor Target: GHRH Receptor (GHRH-R)
• Quantity: 20mg per vial
• Purity: ≥98% (HPLC verified)
• Form: Lyophilised sterile powder
• Packaging: Individually sealed, sterile glass vial
• Storage: 2-8°C (refrigerated). Protect from light and moisture.

What’s Included

Each order includes 1 × 3ml Bacteriostatic Water (BAC Water) for reconstituting the lyophilised powder. No additional reconstitution solution is required.

Key Research Benefits

• Full-Length GHRH Analogue: Complete GHRH 1-44 sequence for authentic receptor binding research.
• GH Axis Studies: Investigates GHRH-GH-IGF-1 signalling from hypothalamus to periphery.
• Somatotroph Function: Research tool for GH secretory dynamics and pulsatile release studies.
• Endocrine Regulation: Explores somatostatin inhibition and feedback loop mechanisms.

Reconstitution Guidelines

For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.

• Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
• Wipe the rubber stopper with an alcohol swab and allow it to dry.
• Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
• Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
• Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
• Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.

Important Notice

This product is for research and laboratory purposes only. Not for human or veterinary consumption. Not for medical use. Not evaluated by SAHPRA. Information is for educational reference only. Researchers must comply with all applicable laws, regulations, and institutional research guidelines.