Description
PT-141 10mg Nasal Spray — Melanocortin Agonist for CNS Receptor Research
What is PT-141 Nasal Spray?
PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide derived from Melanotan II through structural modification. It was engineered to retain melanocortin receptor agonist activity while exhibiting a distinct receptor selectivity and pharmacokinetic profile compared to its parent compound.
PT-141 is a potent agonist of the melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors, which are expressed predominantly in the central nervous system. This nasal spray kit contains lyophilised PT-141 powder, a metered-dose nasal spray bottle and bacteriostatic water for reconstitution. Once reconstituted, the solution is transferred to the spray bottle, enabling research into central melanocortin signalling via the intranasal route.
Mechanism of Research Interest
- MC3R/MC4R Agonism: Selectively activates central melanocortin receptors, enabling research into their physiological roles.
- CNS Signalling: Studied for effects on hypothalamic and brainstem melanocortin pathways.
- Receptor Selectivity: The modified structure allows comparative pharmacology studies against Melanotan II and α-MSH analogues.
- Intranasal Bioavailability: The spray format supports research into intranasal delivery of cyclic peptides to the CNS.
Research Applications
- Central melanocortin receptor research
- Hypothalamic signalling pathway studies
- Peptide receptor selectivity investigations
- Cyclic peptide drug design research
- Intranasal peptide delivery research
Product Specifications
- Compound: PT-141 (bremelanotide)
- Structure: Cyclic heptapeptide
- Sequence Length: 7 amino acids
- Quantity: 10mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilised powder for reconstitution
- Packaging: Lyophilised vial + empty metered-dose spray bottle + Bacteriostatic Water (3ml)
- Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.
What’s Included
This kit includes:
- 1 × Lyophilised PT-141 (10mg) vial
- 1 × Empty metered-dose nasal spray bottle
- 1 × Bacteriostatic Water (3ml)
Quality & Sourcing
All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.
Key Research Benefits
- Central Melanocortin Agonism: Potent MC3R/MC4R agonist for CNS melanocortin signalling research.
- Intranasal Route: Reconstituted solution is transferred to the metered-dose spray bottle for intranasal delivery studies of cyclic peptides.
- Receptor Selectivity Research: Comparative pharmacology against Melanotan II and α-MSH analogues.
- Complete Kit: Includes lyophilised peptide vial, spray bottle and bacteriostatic water — everything needed for intranasal research protocols.
How to Use (Research Application)
For experienced laboratory personnel only. This product is supplied as a lyophilised kit and must be reconstituted before use.
- Allow the peptide vial to equilibrate to room temperature. Wipe the rubber stopper with an alcohol swab.
- Using a sterile syringe, inject the supplied Bacteriostatic Water slowly down the inner wall of the vial.
- Gently swirl until the powder is fully dissolved — do not shake, as this can denature the peptide.
- Draw the reconstituted solution into a sterile syringe and transfer it into the empty metered-dose nasal spray bottle.
- Reattach the spray nozzle and prime the pump 2–3 times until an even mist is produced.
- Follow the administration schedule defined in your research protocol. Store at 2–8°C and use within the timeframe defined in your protocol.
Important Notice
This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.
