Description

Cerebrolysin Vial — Neurotrophic Peptide Preparation for Neuroscience Research (60mg)

What is Cerebrolysin?

Cerebrolysin is a biologically derived peptide preparation obtained from porcine brain tissue through controlled enzymatic breakdown. It contains a mixture of low-molecular-weight peptides (predominantly <10 kDa) and free amino acids that collectively mimic the biological activity of naturally occurring neurotrophic factors. The peptide fraction includes fragments derived from brain-specific proteins, growth factors, and signalling molecules that support neuronal function.

What distinguishes Cerebrolysin from individual synthetic peptides is its multi-component nature — rather than targeting a single receptor or pathway, it provides a complex mixture of bioactive peptides that engage multiple neurotrophic signalling cascades simultaneously. The preparation is standardised such that 1ml of Cerebrolysin concentrate contains approximately 215.2mg of peptide preparation in solution (before lyophilisation).

Neurotrophic Activity Profile

The biological activity of Cerebrolysin is attributed to its ability to modulate several key neurotrophic pathways:

• Nerve Growth Factor (NGF)-Like Activity: The peptide mixture includes fragments that can bind to and activate neurotrophin receptors, mimicking aspects of NGF signalling involved in neuronal survival and differentiation.
• Brain-Derived Neurotrophic Factor (BDNF) Modulation: Components of the preparation have been shown to influence BDNF expression and its downstream signalling through TrkB receptors — a critical pathway for synaptic plasticity and long-term potentiation.
• Glial Cell-Derived Neurotrophic Factor (GDNF) Interactions: Some peptide fragments exhibit activity similar to GDNF, supporting dopaminergic neuron health.
• Antioxidant Signalling: Peptide components modulate cellular antioxidant defence mechanisms and reduce oxidative stress markers in neural tissue models.

Research Applications

• Neuroprotection Studies: Investigating the effect of multi-component neurotrophic stimulation on neuronal survival under stress conditions.
• Synaptic Plasticity Research: Studying how neurotrophic peptide mixtures influence synaptic connectivity, dendritic spine density, and long-term potentiation (LTP).
• Neurogenesis Research: Exploring the effects of peptide preparations on neural stem cell proliferation, differentiation, and integration.
• Neuroinflammation Studies: Researching the effects of neurotrophic stimulation on microglial activation and inflammatory signalling in neural tissue.
• Cognitive Neuroscience: Investigating molecular mechanisms underlying learning and memory processes.

Product Description

Each vial contains 60mg of lyophilised Cerebrolysin peptide preparation as a sterile, freeze-dried composition. The lyophilised form allows for stable long-term storage and reconstitution as needed for research protocols. The powder appears as an off-white to light beige lyophilised cake.

As a biologically derived preparation (rather than a single synthetic peptide), Cerebrolysin’s exact peptide composition varies between batches within a defined standardisation range. Each unit provides consistent biological activity based on standardised production methods.

Product Specifications

• Preparation: Porcine brain-derived neurotrophic peptide preparation
• Composition: Low-molecular-weight peptides (≤10 kDa) and free amino acids
• Quantity: 60mg lyophilised preparation per vial
• Standardisation: Defined peptide profile per established manufacturing protocols
• Form: Lyophilised sterile powder
• Packaging: Individually sealed, sterile glass vial
• Storage: 2-8°C (refrigerated). Protect from light and moisture.

What’s Included

Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.

Key Research Benefits

• Multi-Component Neurotrophic: Peptide mixture with NGF, BDNF and GDNF-like activity profiles.
• Neuroprotection Research: Studied for neuronal survival under stress conditions.
• Synaptic Plasticity: Investigates dendritic spine density and long-term potentiation.
• Antioxidant Signalling: Modulates cellular antioxidant defence in neural tissue models.

Reconstitution Guidelines

For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.

• Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
• Wipe the rubber stopper with an alcohol swab and allow it to dry.
• Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
• Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
• Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
• Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.

Important Notice

This product is for research and laboratory purposes only. Not for human or veterinary consumption. Not for medical use. Not evaluated by SAHPRA. Information is for educational reference only. Researchers must comply with all applicable laws, regulations, and institutional research guidelines.