Description

Semax 10mg Nasal Spray — Synthetic ACTH-Derived Heptapeptide for Neuroscience Research

What is Semax Nasal Spray?

Semax is a synthetic heptapeptide (7 amino acids in length) with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), but unlike its parent hormone, Semax is engineered to eliminate the corticotropic activity of ACTH while retaining and enhancing its neurotrophic and neuroregulatory properties.

This nasal spray kit contains lyophilised Semax powder, a metered-dose nasal spray bottle and bacteriostatic water for reconstitution — reflecting the intranasal route commonly associated with Semax research applications. With a molecular weight of approximately 750 Da, Semax is a relatively small peptide that is well-characterised in the neuroscience literature, with extensive published research examining its effects on cognitive function, neuroprotection, and neural signalling.

Mechanism of Research Interest

• BDNF Upregulation: Semax has been shown to increase the expression of brain-derived neurotrophic factor (BDNF) mRNA and protein levels in hippocampal and cortical neurons.
• TrkB Receptor Signalling: By modulating BDNF levels, Semax indirectly activates TrkB signalling cascades, including the MAPK/ERK and PI3K/Akt pathways involved in neuronal survival and synaptic plasticity.
• NGF Receptor Expression: Research indicates Semax can modulate the expression of nerve growth factor (NGF) receptors, potentially influencing neuronal differentiation and maintenance.
• Monoamine Modulation: Studies suggest Semax influences dopamine and serotonin receptor expression and function in brain regions associated with cognitive processing.

Research Applications

• BDNF-TrkB signalling research
• Neuroplasticity studies
• Neuroprotection research
• Cognitive neuroscience
• Intranasal peptide delivery research

Product Specifications

• Compound: Semax (Synthetic ACTH 4-10 Analogue Heptapeptide)
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Amino Acid Length: 7
• Molecular Weight: ~750 Da
• Quantity: 10mg per vial
• Purity: ≥98% (HPLC verified)
• Form: Lyophilised powder for reconstitution
• Packaging: Lyophilised vial + empty metered-dose spray bottle + Bacteriostatic Water (3ml)
• Storage: 2-8°C (refrigerated). Protect from light and moisture.

What’s Included

This kit includes:

• 1 × Lyophilised Semax (10mg) vial
• 1 × Empty metered-dose nasal spray bottle
• 1 × Bacteriostatic Water (3ml)

Quality & Sourcing

All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.

Key Research Benefits

• Well-Characterised Heptapeptide: Extensively studied ACTH(4-10) analogue with published neuroscience literature.
• BDNF-TrkB Signalling: Research focus on BDNF upregulation and downstream synaptic plasticity cascades.
• Intranasal Delivery: Reconstituted solution is transferred to the metered-dose spray bottle for intranasal peptide delivery and bioavailability research.
• Complete Kit: Includes lyophilised peptide vial, spray bottle and bacteriostatic water — everything needed for intranasal research protocols.

How to Use (Research Application)

For experienced laboratory personnel only. This product is supplied as a lyophilised kit and must be reconstituted before use.

• Allow the peptide vial to equilibrate to room temperature. Wipe the rubber stopper with an alcohol swab.
• Using a sterile syringe, inject the supplied Bacteriostatic Water slowly down the inner wall of the vial.
• Gently swirl until the powder is fully dissolved — do not shake, as this can denature the peptide.
• Draw the reconstituted solution into a sterile syringe and transfer it into the empty metered-dose nasal spray bottle.
• Reattach the spray nozzle and prime the pump 2–3 times until an even mist is produced.
• Follow the administration schedule defined in your research protocol. Store at 2–8°C and use within the timeframe defined in your protocol.

Important Notice

This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.