Description

SS-31 Vial — Mitochondrial-Targeted Peptide for Bioenergetics Research (10mg)

What is SS-31?

SS-31, also known as elamipretide, is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH₂) engineered to selectively target the inner mitochondrial membrane. Its alternating basic and aromatic amino acid structure enables it to concentrate within mitochondria — the organelles responsible for cellular energy production.

The peptide binds to cardiolipin, a phospholipid unique to the inner mitochondrial membrane that is essential for the structural organisation of the electron transport chain. By stabilising cardiolipin, SS-31 is studied for its effects on mitochondrial bioenergetics, reactive oxygen species production and mitochondrial dynamics.

Mechanism of Research Interest

• Cardiolipin Binding: Interacts with cardiolipin to stabilise the inner mitochondrial membrane and preserve electron transport chain integrity.
• Mitochondrial Targeting: The peptide’s sequence design enables selective accumulation within mitochondria — a key feature in targeted delivery research.
• ROS Modulation: Studied for effects on mitochondrial reactive oxygen species production under stress conditions.
• Bioenergetic Studies: Research examines impact on ATP synthesis efficiency and mitochondrial respiration rates.

Research Applications

• Mitochondrial bioenergetics research
• Cardiolipin-membrane interaction studies
• Oxidative stress and ROS biology
• Mitochondrial-targeted peptide design

Product Specifications

• Compound: SS-31 (elamipretide)
• Structure: Tetrapeptide with D-amino acid residues
• Sequence Length: 4 amino acids
• Quantity: 10mg per vial
• Purity: ≥98% (HPLC verified)
• Form: Lyophilised (freeze-dried) sterile powder
• Appearance: White to off-white lyophilised cake
• Packaging: Individually sealed sterile glass vial
• Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.

What’s Included

Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.

Quality & Sourcing

All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.

Key Research Benefits

• Mitochondrial Targeting: Engineered to concentrate in the inner mitochondrial membrane for organelle-level research.
• Cardiolipin Stabilisation: Binds cardiolipin to preserve electron transport chain integrity.
• Bioenergetics Studies: Research tool for ATP synthesis efficiency and mitochondrial respiration assays.
• ROS Modulation: Investigated for effects on mitochondrial reactive oxygen species production.

Reconstitution Guidelines

For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.

• Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
• Wipe the rubber stopper with an alcohol swab and allow it to dry.
• Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
• Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
• Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
• Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.

Important Notice

This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.