Description
PT-141 Vial — Melanocortin Agonist for CNS Receptor Research (10mg)
What is PT-141?
PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide derived from Melanotan II through structural modification. It was engineered to retain melanocortin receptor agonist activity while exhibiting a distinct receptor selectivity and pharmacokinetic profile compared to its parent compound.
PT-141 is a potent agonist of the melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors, which are expressed predominantly in the central nervous system. Research interest centres on the role of central melanocortin signalling in behavioural and autonomic regulation.
Mechanism of Research Interest
- MC3R/MC4R Agonism: Selectively activates central melanocortin receptors, enabling research into their physiological roles.
- CNS Signalling: Studied for effects on hypothalamic and brainstem melanocortin pathways.
- Receptor Selectivity: The modified structure allows comparative pharmacology studies against Melanotan II and α-MSH analogues.
Research Applications
- Central melanocortin receptor research
- Hypothalamic signalling pathway studies
- Peptide receptor selectivity investigations
- Cyclic peptide drug design research
Product Specifications
- Compound: PT-141 (bremelanotide)
- Structure: Cyclic heptapeptide
- Sequence Length: 7 amino acids
- Quantity: 10mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilised (freeze-dried) sterile powder
- Appearance: White to off-white lyophilised cake
- Packaging: Individually sealed sterile glass vial
- Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.
What’s Included
Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.
Quality & Sourcing
All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.
Key Research Benefits
- MC3R/MC4R Agonism: Potent central melanocortin receptor agonist for CNS signalling research.
- Cyclic Peptide Design: Constrained cyclic heptapeptide useful for conformational pharmacology studies.
- Receptor Selectivity: Distinct selectivity profile vs Melanotan II for comparative assays.
- CNS Pathway Research: Studied in hypothalamic and brainstem melanocortin signalling.
Reconstitution Guidelines
For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.
- Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
- Wipe the rubber stopper with an alcohol swab and allow it to dry.
- Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
- Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
- Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
- Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.
Important Notice
This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.
