Description
Melanotan II Vial — Cyclic Melanocortin Agonist for Receptor Research (10mg)
What is Melanotan II?
Melanotan II is a synthetic cyclic peptide analogue of α-melanocyte stimulating hormone (α-MSH). Its cyclic lactam structure — formed by a bridge between specific residues — locks the peptide into a bioactive conformation, increasing its potency and stability compared to linear analogues.
Unlike Melanotan I, which is selective for MC1R, Melanotan II is a broader melanocortin receptor agonist with activity at MC1R, MC3R and MC4R. This broad receptor profile makes it a valuable tool for studying the diverse physiological roles of the melanocortin system.
Mechanism of Research Interest
- Multi-Receptor Agonism: Activates MC1R, MC3R and MC4R, enabling comparative studies of melanocortin receptor subtype signalling.
- Constrained Conformation: The cyclic structure provides a rigid bioactive conformation, useful for receptor binding and conformational studies.
- Melanocortin System Research: The melanocortin system is implicated in pigmentation, energy homeostasis, inflammation and sexual function — all active research areas.
Research Applications
- Melanocortin receptor subtype pharmacology
- Energy homeostasis and feeding behaviour research
- Melanogenesis signalling studies
- Cyclic peptide conformational research
Product Specifications
- Compound: Melanotan II (cyclic α-MSH analogue)
- Structure: Cyclic lactam peptide
- Quantity: 10mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilised (freeze-dried) sterile powder
- Appearance: White to off-white lyophilised cake
- Packaging: Individually sealed sterile glass vial
- Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.
What’s Included
Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.
Quality & Sourcing
All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.
Key Research Benefits
- Multi-Receptor Agonist: Activates MC1R, MC3R and MC4R for melanocortin subtype comparative studies.
- Constrained Conformation: Cyclic lactam structure locks the bioactive conformation for binding studies.
- Broad System Research: Melanocortin system implicated in pigmentation, energy balance and inflammation research.
- Defined Pharmacology: Well-characterised reference compound for melanocortin assays.
Reconstitution Guidelines
For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.
- Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
- Wipe the rubber stopper with an alcohol swab and allow it to dry.
- Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
- Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
- Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
- Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.
Important Notice
This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.
