Description
TB-500 Vial — Thymosin Beta-4 Fragment for Regeneration Research (10mg)
What is TB-500?
TB-500 is a synthetic peptide fragment based on thymosin beta-4 (TB-4), a 43-amino acid protein naturally present in nearly all human cells. The TB-500 sequence corresponds to the active actin-binding region of TB-4, which is the primary domain responsible for its biological activities.
Thymosin beta-4 is the principal actin-sequestering molecule in vertebrate cells, playing a central role in cytoskeletal dynamics. Research interest in TB-500 centres on its influence on cell migration, tissue regeneration and developmental signalling — processes that depend on controlled actin polymerisation.
Mechanism of Research Interest
- Actin Binding: Binds to monomeric (G-)actin, regulating the pool of actin available for filament assembly and cytoskeletal remodelling.
- Cell Migration: Actin dynamics regulated by TB-4 influence directional cell movement, a process central to tissue repair and wound healing models.
- Developmental Signalling: TB-4 is implicated in the expression of matrix metalloproteinases and other factors involved in tissue remodelling and angiogenesis.
Research Applications
- Tissue regeneration and wound healing research
- Actin cytoskeleton dynamics studies
- Cell migration and chemotaxis assays
- Angiogenesis-related signalling research
Product Specifications
- Compound: TB-500 (thymosin beta-4 fragment)
- Source: Thymosin beta-4 (43 aa) derived sequence
- Quantity: 10mg per vial
- Purity: ≥98% (HPLC verified)
- Form: Lyophilised (freeze-dried) sterile powder
- Appearance: White to off-white lyophilised cake
- Packaging: Individually sealed sterile glass vial
- Storage: Store at 2-8°C (refrigerated). Protect from light and moisture.
What’s Included
Note: This product does not contain BAC Water. Bacteriostatic water is available to purchase separately on the Cronopharm store.
Quality & Sourcing
All Cronopharm research products are sourced from reputable manufacturers and undergo quality verification. Each batch is tested for purity using HPLC analysis. We maintain strict cold-chain handling from warehouse to dispatch to ensure product integrity throughout the supply chain.
Key Research Benefits
- Actin Regulation: Binds G-actin to modulate cytoskeletal dynamics research.
- Cell Migration Studies: Actin-based motility central to wound healing and tissue repair models.
- Regeneration Research: Thymosin beta-4 fragment investigated for tissue remodelling.
- Angiogenesis Signalling: Studied for matrix metalloproteinase and vessel formation pathways.
Reconstitution Guidelines
For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.
- Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
- Wipe the rubber stopper with an alcohol swab and allow it to dry.
- Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
- Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
- Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
- Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.
Important Notice
This product is for research and laboratory purposes only. It is not for human or veterinary consumption, not for medical use, and not for self-administration. This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA) or any other regulatory body. The information provided is for educational and reference purposes only and should not be construed as medical advice. Researchers are responsible for ensuring compliance with all applicable laws and institutional guidelines governing the use of research products.
