Description
Tesamorelin 10mg Vial — Synthetic GHRH Analogue for Growth Hormone Axis Research
What is Tesamorelin?
Tesamorelin is a synthetic 44-amino acid peptide analogue of human growth hormone-releasing hormone (GHRH). It is structurally identical to endogenous GHRH(1-44) with the addition of a hexenoyl group at the N-terminus, which enhances its resistance to enzymatic degradation and prolongs its biological activity. This modification allows for sustained activation of the GHRH receptor on somatotroph cells of the anterior pituitary.
Mechanism of Action
Tesamorelin functions as a GHRH receptor agonist. Upon binding to GHRH receptors on pituitary somatotroph cells, it stimulates the synthesis and pulsatile release of growth hormone (GH). The released GH subsequently acts on peripheral tissues to stimulate hepatic insulin-like growth factor 1 (IGF-1) production. This GH/IGF-1 axis is central to numerous physiological processes including protein synthesis, cellular proliferation, and metabolic regulation.
Key Features
• 44-amino acid synthetic GHRH analogue with N-terminal hexenoyl modification
• Enhanced stability and prolonged receptor activation compared to native GHRH
• Lyophilised powder formulation for reconstitution
• 10mg per vial — suitable quantity for extended research protocols
• Research-grade purity
• Manufactured and supplied by Cronopharm South Africa
Research Applications
Tesamorelin is of significant interest in endocrinology and metabolic research, including:
• Growth hormone (GH) and IGF-1 axis signalling pathway studies
• Investigation of GH pulsatility and feedback mechanisms
• Protein synthesis and muscle metabolism research
• Adipose tissue regulation and lipid metabolism studies
• Neuroendocrine regulation and pituitary function
• Age-related decline in GH secretion research
• Metabolic syndrome and body composition studies
Molecular Information
• Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
• Molecular Weight: Approximately 5,135 Da
• Sequence: 44 amino acids with N-terminal hexenoyl group
• Appearance: White to off-white lyophilised powder
Reconstitution and Handling
• Reconstitute with sterile bacteriostatic water or suitable research-grade solvent
• Gently swirl — do not vortex or shake vigorously
• Store reconstituted solution at 2-8°C
• Protect from light and moisture
• For laboratory research use only
Storage Guidelines
• Lyophilised powder: Store at -20°C for long-term storage
• Reconstituted solution: Stable for up to 14 days at 2-8°C
• Protect from repeated freeze-thaw cycles
• Keep desiccated and protected from light
Important Notes
• For laboratory research purposes only
• Not for human or veterinary therapeutic use
• Handle in accordance with institutional biosafety protocols
• Use appropriate personal protective equipment (PPE) when handling
• Supplied by Cronopharm South Africa
What’s Included
Each order includes 1 × 3ml Bacteriostatic Water (BAC Water) for reconstituting the lyophilised powder. No additional reconstitution solution is required.
Key Research Benefits
- GHRH Analogue: Synthetic GHRH 1-44 for growth hormone axis research.
- Endocrine Signalling: Hypothalamic-pituitary-somatotroph pathway investigations.
- Metabolic Research: GH-IGF-1 axis effects on lipid metabolism and body composition.
- Pulsatile Secretion: GH secretory dynamics and feedback regulation studies.
Reconstitution Guidelines
For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.
- Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
- Wipe the rubber stopper with an alcohol swab and allow it to dry.
- Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
- Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
- Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
- Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.
