Description

Cagri Vial — Long-Acting Amylin Analogue for Metabolic Pathway Research (6mg)

What is Cagri?

Cagri is a long-acting synthetic analogue of the naturally occurring pancreatic hormone amylin (also known as islet amyloid polypeptide or IAPP). Native amylin is a 37-amino acid peptide that is co-secreted with insulin by the pancreatic beta cells in response to nutrient intake. Cagri incorporates structural modifications including amino acid substitutions and fatty acid acylation to improve its pharmacokinetic profile and stability compared to native amylin.

Amylin itself belongs to the calcitonin family of peptides and shares structural homology with calcitonin, calcitonin gene-related peptide (CGRP), and adrenomedullin. By studying amylin analogues like Cagri, researchers can explore this less-characterised branch of metabolic hormone signalling.

Receptor Pharmacology

Cagri binds to the amylin receptor (AMYR), which is a heterodimer complex consisting of the calcitonin receptor (CTR) combined with receptor activity-modifying proteins (RAMPs). Specifically, AMYR1 (CTR + RAMP1), AMYR2 (CTR + RAMP2), and AMYR3 (CTR + RAMP3) represent distinct amylin receptor subtypes with different tissue distributions and pharmacological profiles. Amylin receptors are expressed in the area postrema of the brainstem, the hypothalamus, the kidneys, and the gastrointestinal tract.

The long-acting nature of Cagri — achieved through the addition of a fatty acid side chain that promotes albumin binding — results in sustained receptor engagement that allows for extended observation periods in research protocols.

Research Focus Areas

• Amylin Signalling Pathways: Investigating the role of amylin receptors in appetite regulation, satiety signalling, and gastric emptying mechanisms.
• Area Postrema Research: Studying the circumventricular organ as a key site for amylin-mediated satiety signalling.
• Pancreatic Hormone Axis: Exploring how amylin signalling interacts with and complements insulin and incretin pathways.
• Gastric Function Studies: Researching the effects of amylin receptor activation on gastric emptying, gut motility, and nutrient absorption.
• Receptor Subtype Pharmacology: Investigating differential signalling through AMYR1, AMYR2, and AMYR3 subtypes across tissue types.

Product Description

Each vial contains 6mg of lyophilised Cagri peptide powder. The peptide is supplied as a sterile, freeze-dried preparation in a sealed glass vial. The lyophilised format ensures compound stability during transport and storage, and is designed for reconstitution prior to research use.

The powder appears as a white to off-white lyophilised cake. Manufactured under controlled laboratory conditions with quality testing to verify peptide purity.

Product Specifications

• Compound: Cagri (Long-Acting Amylin / IAPP Analogue)
• Hormone Class: Calcitonin family peptide
• Receptor Target: Amylin Receptors (AMYR1, AMYR2, AMYR3)
• Quantity: 6mg per vial
• Purity: ≥98% (HPLC verified)
• Key Modification: Fatty acid acylation for extended half-life
• Form: Lyophilised sterile powder
• Packaging: Individually sealed, sterile glass vial
• Storage: 2-8°C (refrigerated). Protect from light and moisture.

Use Considerations

For experienced laboratory personnel only. Appropriate PPE should be worn during handling. Reconstitute with bacteriostatic water or sterile research-grade diluent. Avoid vigorous shaking during reconstitution to maintain peptide integrity.

Quality & Sourcing

Cagri is sourced from verified peptide manufacturers and quality-tested before dispatch. HPLC analysis confirms purity levels. Cronopharm maintains cold-chain logistics for all temperature-sensitive peptide shipments.

What’s Included

Each order includes 1 × 3ml Bacteriostatic Water (BAC Water) for reconstituting the lyophilised powder. No additional reconstitution solution is required.

Key Research Benefits

• Long-Acting Amylin Analogue: Extended-activity amylin/IAPP analogue for satiety signalling research.
• Receptor Subtype Studies: Differential AMYR1, AMYR2 and AMYR3 pharmacology across tissues.
• Area Postrema Research: Circumventricular organ signalling — key amylin research site.
• Pancreatic Axis Studies: Amylin-insulin-incretin interaction research.

Reconstitution Guidelines

For experienced laboratory personnel only. This lyophilised powder must be reconstituted with bacteriostatic water prior to research use.

• Allow the vial to equilibrate to room temperature (15–25°C) before reconstitution.
• Wipe the rubber stopper with an alcohol swab and allow it to dry.
• Using a sterile syringe, add the required volume of Bacteriostatic Water by injecting slowly down the inner wall of the vial — do not aim the stream directly at the lyophilised cake.
• Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
• Visually inspect the reconstituted solution — it should be clear and free of particulate matter.
• Store reconstituted solutions at 2–8°C and use within the timeframe defined in your research protocol. Discard any unused solution after the recommended period.

Important Notice

This product is for research and laboratory purposes only. Not for human or veterinary consumption. Not for medical or therapeutic use. Not evaluated by SAHPRA. Information is for educational reference only. Researchers are responsible for compliance with all applicable laws, regulations, and institutional research guidelines.